Semaglutide Dilution Calculator

The Semaglutide Dilution Calculator determines the exact stock solution and diluent volumes needed based on your initial and desired concentration levels. This tool helps pharmacists and healthcare professionals prepare accurate medication mixtures quickly and safely. Whether you are compounding specific dosages, adjusting commercial strengths, or preparing liquid formulations, this calculator ensures precision for every patient.

Concentration of the stock semaglutide solution
Target concentration after dilution
Total volume of diluted solution needed

How Required Stock Solution Volume Is Calculated

The Required Stock Solution Volume represents the exact amount of concentrated semaglutide you need to draw from the stock bottle to achieve your target strength.

V₁ = (C₂ × V₂) / C₁

Where:

  • V₁ = Volume of stock solution needed (mL)
  • C₁ = Initial concentration of stock solution (mg/mL)
  • V₂ = Final total volume of diluted solution (mL)
  • C₂ = Desired final concentration (mg/mL)
  1. Multiply the desired concentration by the final total volume to find the total amount of drug needed.
  2. Divide the total drug amount by the initial stock concentration to find the stock volume.
  3. Subtract the stock volume from the final total volume to calculate the required diluent amount.

What Your Required Stock Solution Volume Means

This calculated volume provides the precise measurements needed to create a homogeneous solution that matches the prescribed dosage strength for safe administration.

  • Titration Protocols: For patients starting therapy, results will typically indicate a small stock volume mixed with a larger amount of diluent (e.g., resulting in 0.25 mg/mL) to minimize side effects.
  • Maintenance Dosing: For established patients on higher doses, the calculation may show a higher stock volume ratio to achieve therapeutic concentrations (e.g., 1.0 mg/mL or higher).
  • Compounding: When preparing custom batches, ensure your final volume matches the container size to avoid overflow or significant waste.

Important: Always verify that the selected diluent is compatible with semaglutide to maintain stability and prevent precipitation.

This calculator is for informational purposes only and does not constitute medical advice. Always verify calculations and consult manufacturer guidelines or a qualified pharmacist before preparing medications.

After mixing, label the container clearly with the new concentration, date, time, and storage requirements to ensure safety.