Retatrutide Dosage Calculator

Calculate the appropriate retatrutide dosage for weight loss based on your weight and treatment phase. This tool helps determine your current and target maintenance doses following clinical titration schedules.

Weight Enter your current body weight

Weight Unit

Current Treatment Week Week number of your current treatment cycle (1-48)

Target Maintenance Dose

Medication Tolerance: Good 1 = Poor tolerance, 2 = Good tolerance, 3 = Excellent tolerance

I have type 2 diabetes

Quick Examples:

How to Use This Calculator

Enter your current weight in either kilograms or pounds
Select your current treatment week (1-48)
Choose your target maintenance dose based on your healthcare provider's recommendation
Adjust the tolerance slider based on how well you tolerate the medication

Dosage Calculation Method

Current Dose = f(Week, Tolerance, Target Dose)

Dosing Schedule:

Weeks 1-4: Starting dose (0.25-0.5 mg)
Weeks 5-8: Dose escalation (1-2 mg)
Weeks 9-16: Intermediate dose (4-8 mg)
Weeks 17+: Maintenance dose (8-12 mg)

Example Calculation

Real-World Scenario:

A patient weighing 90 kg (198 lbs) is in week 12 of treatment with a target maintenance dose of 8 mg and good tolerance.

Given:

Weight = 90 kg
Treatment Week = 12
Target Dose = 8 mg
Tolerance = Good (2)

Calculation:

Based on the titration schedule, week 12 falls in the intermediate dose phase (weeks 9-16). With good tolerance, the patient can be escalated to 4 mg at this stage.

Result: Current dose = 4 mg weekly, with planned increase to 8 mg at week 17.

Why Proper Dosage Matters

Clinical Benefits

Optimal weight loss results (15-24% in clinical trials)
Reduced side effects through gradual titration
Improved blood sugar control in diabetic patients

Safety Considerations

Minimizes gastrointestinal side effects
Reduces risk of hypoglycemia in diabetic patients
Allows for individualized treatment plans

Common Mistakes & Tips

Jumping directly to higher doses without proper titration increases the risk of severe side effects. Always follow the recommended escalation schedule, even if you feel well at lower doses.

If you experience persistent nausea, vomiting, or other side effects, consult your healthcare provider before continuing with the same dose. You may need to pause treatment or return to a lower dose temporarily.

Retatrutide should be administered consistently on the same day each week. Missing doses or changing administration days can reduce effectiveness and increase side effects when you resume treatment.

Frequently Asked Questions

Most patients begin to see weight loss within the first 4-8 weeks of treatment. However, significant results typically become more apparent after reaching the maintenance dose (around week 16-20). In clinical trials, patients lost an average of 5-8% of their body weight by week 24 and up to 24% by week 48.

Dose adjustments should always be made in consultation with your healthcare provider. While the calculator provides general guidance, your provider may recommend staying at a certain dose longer or adjusting the titration schedule based on your individual response, side effects, and weight loss progress.

If you miss a dose and it's within 3 days of your scheduled dose, take it as soon as you remember. If it's been more than 3 days, skip the missed dose and take your next dose on the regularly scheduled day. Do not take two doses at the same time or increase your next dose to make up for the missed one.

References & Disclaimer

Medical Disclaimer

This calculator is for informational purposes only and does not constitute medical advice. The dosage recommendations provided are based on clinical trial data and general guidelines. Always consult with your healthcare provider before starting, adjusting, or discontinuing any medication. Your healthcare provider will determine the appropriate dosage based on your individual health status, medical history, and treatment response.

References

Retatrutide for Obesity — Phase 2 Trial - New England Journal of Medicine, 2023
Efficacy and safety of retatrutide in adults with obesity - Nature Medicine, 2023
Retatrutide in Type 2 Diabetes: Phase 2 Trial - Diabetes, 2023

Accuracy Notice

This calculator provides estimates based on available clinical data. Individual results may vary. The actual dosage prescribed by your healthcare provider may differ based on factors not included in this calculator, such as kidney function, liver function, concurrent medications, and other health conditions.

About the Author

Kumaravel Madhavan

Web developer and data researcher creating accurate, easy-to-use calculators across health, finance, education, and construction and more. Works with subject-matter experts to ensure formulas meet trusted standards like WHO, NIH, and ISO.

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health medical-clinical-calculators retatrutide dosage medical body weight

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