Compounded Tirzepatide Dosage Calculator
Calculate appropriate compounded tirzepatide dosages, titration schedules, and treatment requirements based on patient-specific factors and clinical guidelines.
How to Use This Calculator
- Enter the patient's weight in kilograms
- Select the treatment indication (Type 2 Diabetes or Weight Management)
- Enter the current dose if the patient is already on treatment
- Select the target dose based on treatment goals
- Choose the compounding concentration available
- Select the patient's renal function status
- Adjust treatment duration using the slider
- Check if the patient has GI sensitivity for slower titration
Formula Used
Dose Volume (mL) = Target Dose (mg) ÷ Concentration (mg/mL)
Titration Interval = Standard Interval × GI Factor
Where:
- Target Dose = Selected therapeutic dose (5mg, 10mg, or 15mg)
- Concentration = Compounded formulation strength (5mg/mL, 10mg/mL, or 15mg/mL)
- Standard Interval = 4 weeks for normal titration
- GI Factor = 1.0 for normal patients, 1.5 for patients with GI sensitivity
Example Calculation
Real-World Scenario:
A 75kg patient with Type 2 Diabetes is starting tirzepatide treatment. The patient has normal renal function and no GI sensitivity. The target dose is 10mg using a 5mg/mL compounded formulation.
Given:
- Patient Weight = 75 kg
- Indication = Type 2 Diabetes
- Current Dose = 0 mg (treatment-naive)
- Target Dose = 10 mg
- Concentration = 5 mg/mL
- Renal Function = Normal
- GI Sensitivity = No
Calculation:
Starting dose = 2.5 mg
Starting volume = 2.5 mg ÷ 5 mg/mL = 0.5 mL
Titration schedule:
- Weeks 1-4: 2.5 mg (0.5 mL)
- Weeks 5-8: 5 mg (1.0 mL)
- Weeks 9-12: 7.5 mg (1.5 mL)
- Weeks 13+: 10 mg (2.0 mL)
Result: Patient will reach target dose of 10mg (2.0 mL) by week 13 with standard 4-week titration intervals.
Why This Calculation Matters
Practical Applications
- Prevents dosing errors in compounded formulations
- Optimizes titration schedules for individual patients
- Helps manage medication costs by calculating exact volumes
- Supports clinical decision-making for special populations
Key Benefits
- Reduces gastrointestinal side effects through proper titration
- Improves medication adherence with clear dosing schedules
- Enhances treatment outcomes with personalized dosing
- Provides guidance for patients with renal impairment
Common Mistakes & Tips
Frequently Asked Questions
References & Disclaimer
Medical Disclaimer
This calculator provides estimates based on clinical guidelines for tirzepatide dosing. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider before making any decisions about medication dosing. The information provided here is for educational purposes only.
References
- Mounjaro® (tirzepatide) Prescribing Information - Official FDA-approved prescribing information for tirzepatide in type 2 diabetes
- Zepbound® (tirzepatide) Prescribing Information - Official FDA-approved prescribing information for tirzepatide in weight management
- Tirzepatide: A Review of its Efficacy and Safety - Comprehensive review of tirzepatide clinical trials and outcomes
Accuracy Notice
This calculator follows standard titration protocols for tirzepatide based on current clinical guidelines. Individual patient factors may require adjustments to the recommended dosing schedule. Healthcare providers should use their clinical judgment when determining appropriate dosing for individual patients, especially those with comorbidities or taking multiple medications.
About the Author
Kumaravel Madhavan
Web developer and data researcher creating accurate, easy-to-use calculators across health, finance, education, and construction and more. Works with subject-matter experts to ensure formulas meet trusted standards like WHO, NIH, and ISO.